Modification of Factor VIII
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United States of America Patent
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Issued Date -
Dec 15, 2011
app pub date -
Feb 18, 2010
filing date -
Feb 19, 2009
priority date (Note) -
Abandoned
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Abstract
A Factor VIII derivative of formula (I): wherein: B represents C.sub.2 to C.sub.10 alkylene; m represents 0 or an integer from 1 to 19, n represents an integer from 1 to 20, and the sum of m and n is from 1 to 20; P represents a mono or polyradical of Factor VIII obtained by removing m+n carbamoyl groups from the side chains of glutamine residues in Factor VIII; and M represents a moiety (M.sup.1) that increases the plasma half-life of the Factor VIII derivative or a reporter moiety (M.sup.2); or a pharmaceutically acceptable salt thereof. ##STR00001##
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