CANCER DRUG DELIVERY USING MODIFIED TRANSFERRIN
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United States of America Patent
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Issued Date -
Nov 24, 2011
app pub date -
Dec 6, 2010
filing date -
Jun 8, 2007
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Abstract
The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic agents are chemotherapeutic agents. The modified Tf molecules improve the delivery of the conjugated agent to a target tissue. In some embodiments, the modified Tf molecule has a mutation which decreases the release of bound iron from a Tf complex. The complex can also contain, for instance, a carbonate, oxalate, or other anion to stabilize the Tf iron complex.
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