PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINE DERIVATIVE

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United States of America Patent

APP PUB NO 20110287494A1
SERIAL NO

13060986

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Abstract

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Novel enzymes that stereoselectively reduce imine derivatives were isolated and purified, and polynucleotides encoding the enzymes were cloned. Optically active amine derivatives were produced by acting on imine derivatives with a culture of microorganisms having the ability to stereoselectively reduce the compounds, microbial cells or processed products thereof, and/or imine reductases thereof, followed by collecting the generated optically active amine derivatives. The present invention enables, for example, production of an optically active compound represented by formula (IV):(wherein R group represents an alkyl group having one to three carbon atoms; and n represents an integer of 1 to 4).

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Patent Owner(s)

Patent OwnerAddress
DAICEL CHEMICAL INDUSTRIES LTD1-BANCHI TEPPO-CHO SAKAI-SHI OSAKA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ishida, Koichi Gifu, JP 116 869
Kimoto, Norihiro Hyogo, JP 26 177
Nagasawa, Toru Gifu, JP 31 144
Yamamoto, Hiroaki Hyogo, JP 438 4133
Yoshida, Toyokazu Gifu, JP 5 1

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