METHOD FOR IDENTIFYING INHIBITORS OF LIPOTEICHOIC ACID SYNTHASE
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United States of America Patent
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Issued Date -
Nov 17, 2011
app pub date -
Dec 4, 2009
filing date -
Dec 5, 2008
priority date (Note) -
Abandoned
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Abstract
The invention provides a method of identifying an inhibitor of LtaS comprising: (a) providing bacteria which comprise a mutation in the mbl gene or homologue thereof; (b) culturing the bacteria of (a) in the presence of a test substance under conditions of low magnesium; (c) monitoring the growth of the bacteria; wherein growth or more rapid growth of the bacteria compared to growth in the absence of the test substance is indicative that the test substance is an inhibitor of LtaS.
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