Compositions and methods for treating amyloidosis

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United States of America Patent

APP PUB NO 20110281951A1
SERIAL NO

13066451

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Therapeutic compounds and methods for modulating amyloid aggregation in a subject, whatever its clinical setting, are described. Amyloid aggregation is modulated by the administration to a subject of an effective amount of a therapeutic compound of the formulais not a hydrogen atom. In an embodiment, at least one of k or m must equal 1. “p” and “s” are each independently positive integers selected such that the biodistribution of the therapeutic compound for an intended target site is not prevented while maintaining activity of the therapeutic compound. T is a linking group and Y is a group of the formula -A X wherein A is an anionic group at physiological pH, and X is a cationic group.

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Patent Owner(s)

Patent OwnerAddress
BHI LIMITED PARTNERSHIP275 ARMAND-FRAPPIER BOULEVARD LAVAL QUEBEC H7V 4A7

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gordon, Heather St. Catharines, CA 4 62
Kong, Xianqi Dollard-des-Ormeaux, CA 84 724
Szarek, Walter Kingston, CA 14 245
Weaver, Donald Halifax, CA 19 251

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