PROCESS FOR PLASMID DNA FERMENTATION
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United States of America Patent
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Issued Date -
Nov 17, 2011
app pub date -
May 16, 2011
filing date -
Aug 19, 2004
priority date (Note) -
Abandoned
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Abstract
Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity in a fermentor. These processes feature fed-batch fermentation strategies, combined with novel growth and induction phase temperature shifts.
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