EFFICIENT DETECTION OF DOUBLE MUTANTS OF THE CEBPA GENE IN ACUTE MYELOID LEUKEMIA
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Issued Date -
Nov 17, 2011
app pub date -
Nov 13, 2009
filing date -
Nov 13, 2008
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Abandoned
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Abstract
The invention is in the field of molecular diagnostics for cancer, in particular, for acute myeloid leukemia (AML). The invention provides methods for diagnosing AML patients with a favorable prognosis. We have found that not all AML patients carrying a CEBPA mutation may have a more favorable prognosis. We found that only the group with double mutations, i.e., biallelic mutations, have a particularly favorable prognosis. We also found a method that distinguishes mono-allelic CEBPA mutations from bi-allelic mutations.
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