Antibody-Guided Fragment Growth
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United States of America Patent
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Issued Date -
Nov 10, 2011
app pub date -
Jan 12, 2010
filing date -
Jan 12, 2009
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Abandoned
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Abstract
The present invention relates to an improved method for drug discovery comprising using contact residue information derived from antibody-protein target interactions to help to direct the growth of small molecule fragments during the synthesis of a drug candidate. In particular, the present invention relates to the use of atomic structural information derived from anti-body-protein interactions to guide the growth of small molecular fragments during lead optimisation, thus generating small molecule compounds which can alter the biological activity of a target protein.
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