METHODS AND KITS FOR ANALYZING POLYNUCLEOTIDE SEQUENCES
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United States of America Patent
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app pub date -
May 5, 2011
filing date -
Feb 19, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention features methods for analyzing a sequence of a target polynucleotide by detecting incorporation of a nucleotide into its complementary strand, where the polynucleotides may be bound at high density and at single molecule resolution. The invention also features labeling moieties and blocking moieties, which facilitate chain termination or choking. Certain aspects provide for temporal detection of the incorporations; some allow for asynchronous analysis of a plurality of target polynucleotides and the use of short sequencing cycles. Surface chemistry aspects of the sequencing methods are also provided. The method may also be used in kits, said kits designed to carry out and facilitate the methods provided herein.
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- 7 Citation Count
- C12Q Class
- 10.22 % this patent is cited more than
- 14 Age