PHOSPHORYLATED FMS-RELATED TYROSINE KINASE 3 BIOMARKER ASSAY
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United States of America Patent
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Issued Date -
Nov 10, 2011
app pub date -
Nov 6, 2009
filing date -
Nov 6, 2008
priority date (Note) -
Abandoned
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Abstract
Provided herein are methods for detecting the presence of human pFLT3 in a sample. An exemplary assay provided herein is an ELISA method (e.g., sandwich ELISA). Also provided herein are methods for detecting FLT3 phosphorylation in a sample, diagnosing a patient having a FLT3-activating mutation, identifying a compound that activates or is otherwise and agonist of human FLT3 phosphorylation, identifying a compound that inhibits or is otherwise an antagonist of human FLT3 phosphorylation, determining the efficacy of a compound for increasing, decreasing or otherwise modulating human FLT3 phosphorylation in a patient. Further provided are kits for carrying out the said methods. Such kits comprise at least a total FLT3 antibody optionally immobilized on a solid support and a labeled pFLT3 antibody.
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