Modified Thromboxane A2 Receptor Promoter Sequence
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United States of America Patent
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Issued Date -
Nov 3, 2011
app pub date -
Aug 11, 2009
filing date -
Aug 11, 2008
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Abandoned
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Abstract
The invention provides nucleic acid sequences useful in regulating the transcription of a gene. In particular, the invention relates to a promoter sequence, and variants thereof, that can be used to differentially regulate the transcription of a gene. The present invention, accordingly, provides methods for regulating transcription of a gene, the method comprising providing a gene transcription-regulating polynucleotide in operable association with the gene, optionally within a host cell, wherein the gene transcription-regulating polynucleotide comprises the nucleic acid sequence of SEQ ID NO:1 of the nucleic acid sequence of thromboxane A2 receptor promoter or a fragment thereof, the gene transcription-regulating polynucleotide or the fragment thereof further comprising at least one nucleic acid modification and/or substitution. The nucleic acid sequences and probes of the present invention also find utility as predictive markers for alterations in gene transcription in disease settings; or can be used to achieve over-expression of recombinant proteins in mammalian cells. Accordingly, the present invention also provides recombinant expression vectors and host cells for use in regulating the transcription of a gene.
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