NUCLEAR RECEPTOR SENSOR SYSTEM IN TRANSGENIC ANIMAL
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United States of America Patent
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Issued Date -
Oct 27, 2011
app pub date -
Sep 3, 2009
filing date -
Sep 5, 2008
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Abandoned
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Abstract
A sensor system for detecting the activation of specific nuclear receptors in a tissue of an animal is provided. The nuclear receptor sensor system comprises a sensor component comprising a nuclear receptor or part thereof coupled to a DNA-binding domain, and a reporter component comprising a reporter gene. Transgenic animals, such as a transgenic pig is provided, which comprises the components of the nuclear receptor sensor system in its genome. Also methods of producing the transgenic animal is provided as well as use of the transgenic animal for evaluating the activity of a nuclear receptor in vivo.
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