CONJUGATES FOR THE TREATMENT OF MESOTHELIOMA
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United States of America Patent
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Issued Date -
Oct 27, 2011
app pub date -
May 12, 2009
filing date -
May 13, 2008
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Abstract
The present invention provides conjugates of cytokines and targeting peptides that is able to bind to a receptor expressed on tumor-associated vessels or to a component of the extracellular matrix associated to the tumor vessels, for treatment of malignant pleural mesothelioma. In particular, the invention provides conjugates comprising the cytokine TNF linked to a peptide containing the NGR motif. The invention further provides pharmaceutical compositions comprising such conjugate and pharmaceutical formulations comprising conjugates dissolved in appropriate buffers.
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