COMPOSITIONS AND METHODS FOR GENERATION OF PLURIPOTENT STEM CELLS
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United States of America Patent
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Issued Date -
Oct 27, 2011
app pub date -
Aug 20, 2009
filing date -
Aug 20, 2008
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Abandoned
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Abstract
The present invention describes the use of pre-trans-splicing molecules (PTMs) to reprogram human normal and diseased somatic cells into pluripotent stem cells using spliceosome-mediated RNA trans-splicing. More specifically, the present invention describes the use of the SMaRT™ technology to repair or reprogram the newly induced diseased pluripotent stem cells.
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