METHODS FOR ISOLATING ENVELOPED VIRUS-BASED VLPS FREE OF INFECTIOUS AGENTS
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United States of America Patent
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app pub date -
Nov 3, 2009
filing date -
Nov 3, 2008
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Abstract
Enveloped virus-based virus-like particles (VLPs) that are free of infectious agents and substantially as immunogenic as corresponding VLPs prior to inactivation of infectious agents are described. Improved methods of inactivation infectious agents in preparations of enveloped virus-based VLPs are also described wherein the methods do not adversely affect the immunogenicity of the VLPs.
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