Method for preparing 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil)

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United States of America Patent

PATENT NO 8324412
APP PUB NO 20110257142A1
SERIAL NO

12987850

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Abstract

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The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).

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Patent Owner(s)

Patent OwnerAddress
BAYER INTELLECTUAL PROPERTY GMBHGERMANY MONHEIM BAVARIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bahl, Klaus Herne, DE 2 0
Bohlmann, Ulf Köln, DE 3 2
Eilers, Robert Jena, DE 6 30
Erhart, Bernd Kahla, DE 5 1
Gerecke, Hagen Jena, DE 13 344
Gliesing, Sabine Jena, DE 11 108
Grawe, Detlef Kleinromstedt, DE 17 161
Hoesel, Peter Jena, DE 9 98
Jacke, Jürgen Unna, DE 1 0
Knabe, Uwe Trockenborn, DE 8 23
Michel, Thomas Leipzig, DE 22 587
Mosebach, Michael Berlin, DE 2 0
Mueller, Uwe Jena, DE 51 2169
Sander, Michael Frechen, DE 37 176
Tilstam, Ulf Hoegaarden, BE 9 31
Voigtlaender, David Bad Vilbel, DE 5 6
Wehmeier, Dieter Bergkamen, DE 2 0

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