MATERIAL FOR FILLING BONE DEFECTS AND PRODUCTION METHOD THEREOF
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United States of America Patent
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Issued Date -
Oct 6, 2011
app pub date -
Mar 29, 2011
filing date -
Mar 31, 2010
priority date (Note) -
Abandoned
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Abstract
A material for filling bone defects has a flocculent three-dimensional structure composed of a fibrous substance containing a biodegradable resin as a principal component and further containing a siloxane. The material is produced by dissolving or suspending a substance in a solvent to give a solution or slurry of the substance, the substance containing the biodegradable resin as a principal component and further containing the siloxane, the solution or slurry having such a viscosity as to form a fibrous substance having an average diameter of 10 μm or more; and carrying out electrospinning of the solution or slurry, in which the electrospinning is performed with air blowing. The flocculent three-dimensional structure is expected to show high cell invasion efficiency, because a two-dimensionally structured nonwoven fabric shows high cell invasion efficiency when it has an average diameter of 10 μm or more.
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