ASSESSMENT OF SUBCHONDRAL BONE REMODELLING BY MEASURING CATHEPSIN K FRAGMENTS OF COLLAGEN TYPE II
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United States of America Patent
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Issued Date -
Oct 6, 2011
app pub date -
Nov 11, 2009
filing date -
Nov 13, 2008
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Abandoned
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Abstract
A method of assay to determine the extent of collagen type II resorption activity comprising measuring the level of fragments of collagen type II that contain a cathepsin K generated neo-epitope not shared by collagen type I by binding the neo-epitope with an antibody specific for the neo-epitope and detecting the level of binding of said binding partner.
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