SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES
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United States of America Patent
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Issued Date -
Sep 29, 2011
app pub date -
Feb 16, 2011
filing date -
Mar 29, 2010
priority date (Note) -
Abandoned
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Abstract
Embodiments herein relate to histone deacetylaces (HDACs) and HDAC inhibitors, such as trichostatin A (TSA) and TSA analogues. Embodiments provide simple methods of synthesizing TSA and TSA analogues. These methods provide routes of synthesis of TSA and TSA analogues that enable the production of the HDAC inhibitors at lower cost and in greater quantities than previously were available.
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