TREATMENT OF ACUTE MYOCARDIAL INFARCTION (AMI) USING ENCAPSULATED CELLS ENCODING AND SECRETING GLP-1 PEPTIDES OR ANALOGS THEREOF

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United States of America Patent

SERIAL NO

13061404

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Abstract

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The present application refers to the use of cells, e.g. mesenchymal stem cells or mesenchymal stromal cells, or any further suitable cell, encoding and secreting GLP-1, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof, for the treatment of acute myocardial infarction (AMI or Ml), wherein the cells, encoding and secreting GLP-1, a fragment or variant thereof or a fusion peptide comprising GLP-1 or a fragment or variant thereof, are encapsulated in a (spherical) microcapsule to prevent a response of the immune system of the patient to be treated. The present application also refers to the use of these (spherical) microcapsule(s) or of a pharmaceutical composition containing these cells or (spherical) microcapsule(s) for the treatment of acute myocardial infarction (AMI or Ml).

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Patent Owner(s)

Patent OwnerAddress
BIOCOMPATIBLES UK LTDSURREY SURREY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lewis, Andrew Lennard Surrey, GB 72 720
Stratford, Peter William Surrey, GB 39 1532
Thoenes, Eric Budingen, DE 9 53
Wallrapp, Christine Grossostheim, DE 10 58

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