TEMPLATE-FIXED PEPTIDOMIMETICS
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United States of America Patent
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app pub date -
Aug 8, 2008
filing date -
Aug 8, 2008
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Abandoned
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Abstract
Template-fixed β-hairpin peptidomimetics of the general formulawherein Z is a template-fixed chain of 8 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have agonizing or antagonizing activity against urotensin II or show inhibition of the STAT6/NCoA-1 interaction and can be used for preventing or treating diseases or disorders related to urotensin II, STAT6 and NCoA-1.These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
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