USE OF 2'-DEOXY-4'-THIOCYTIDINE AND ITS ANALOGUES AS DNA HYPOMETHYLATING ANTICANCER AGENTS
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United States of America Patent
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Issued Date -
Sep 8, 2011
app pub date -
Mar 2, 2010
filing date -
Mar 2, 2010
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Abandoned
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Abstract
Compounds represented by the formulae:wherein R is individually selected from the group consisting of H, aliphatic acyl, aromatic acyl group, fluoro, chloro, bromo, iodo, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano, aryl and nitro; pharmaceutically acceptable salts thereof, prodrugs thereof, solvates thereof and mixtures thereof; are used as inhibitors of DNA methyltransferase and for treating patients suffering from diseases resulting from or related to aberrant DNA methylation such as myelodysplastic syndromes and other cancers.
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