NOVEL DIAGNOSTIC METHOD
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United States of America Patent
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Issued Date -
Sep 1, 2011
app pub date -
Feb 18, 2011
filing date -
Feb 18, 2010
priority date (Note) -
Abandoned
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Abstract
A method of monitoring treatment of an inflammatory disease or an inflammatory associated disease with the use of the ratio of N-terminal pyroglutamate modified MCP-1 (MCP-1 N1pE):total concentration of MCP-1 within a biological sample as a biomarker, and a method for determining the proportion of N-terminal pyroglutamate modified MCP-1 in relation to the total concentration of MCP-1 in biological samples. Also disclosed are a diagnostic kit and a method for screening a glutaminyl cyclase (QC) inhibitor or measuring the effectiveness of a glutaminyl cyclase (QC) inhibitor.
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