METHOD FOR PRODUCING GLYCOPROTEIN CHARACTERIZED BY SUGAR CHAIN STRUCTURE BY USING SILKWORM
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United States of America Patent
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Issued Date -
Aug 18, 2011
app pub date -
Jun 15, 2009
filing date -
Feb 29, 2008
priority date (Note) -
Abandoned
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Abstract
It is an object of the present invention to investigate what kinds of structures a sugar chain has by performing a sugar chain structural analysis of a glycoprotein produced in a transgenic silkworm. For the sugar chain of the glycoprotein produced in the transgenic silkworm, a glycoprotein having a sugar chain structure in which fucose is not linked to N-acetylglucosamine at a reducing terminal of the sugar chain is obtained. In addition, a glycoprotein having an almost completely humanized sugar chain structure is obtained by further integrating GalT gene into this transgenic silkworm.
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