EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS
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United States of America Patent
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Issued Date -
Aug 18, 2011
app pub date -
Oct 2, 2008
filing date -
Jul 31, 2008
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Abandoned
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Abstract
The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using dental pulp stem cells as a source of somatic cells, the efficiency of establishment of human iPS cells by transfer of 3 or 4 factors can be improved dramatically. Additionally, dental pulp stem cells are easily available because they can be isolated and prepared from extracted wisdom teeth and teeth extracted because of periodontal disease and the like, so that they can be used widely as a source of somatic cells for iPS cell banks.
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