USE OF ERYTHROPOIETIN TO DEVELOP SMALL MOLECULE INHIBITORS OF JANUS KINASE-2
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United States of America Patent
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Issued Date -
Aug 18, 2011
app pub date -
Jul 29, 2008
filing date -
Aug 2, 2007
priority date (Note) -
Abandoned
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Abstract
The invention pertains to a method for identifying compounds that inhibit the erythropoietin-induced JAK2 kinase activity in vivo. The present invention provides a method for detecting small molecule JAK2 inhibitors in a rapidly created rodent model that phenocopies human PV through Epo stimulation. The method comprises the steps of (a) dosing a rodent with erythropoietin (Epo) and a test compound, (b) collecting blood samples after the dose is administered, (c) measuring phosphorylated STAT5 levels in the blood sample, and (d) determining JAK2 inhibitor levels in the blood samples.
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