CYTOKINE DESIGN
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United States of America Patent
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Issued Date -
Aug 18, 2011
app pub date -
Nov 21, 2008
filing date -
Nov 23, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention relates to novel cytokines, which have a modified selectivity/specificity for their cognate receptors. In particular, the invention relates to a variant TRAIL protein, which has superior selectivity for the death receptor 4 (TRAIL-RI) over the death receptor 5 (TRAIL-R2). In addition, the invention relates to a variant TRAIL protein which exhibits superior selectivity for the death receptor 4 (TRAIL-R1) over the decoy receptors DcR1 (TRAIL-R3) and DcR2 (TRAIL-R4).
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