METHOD OF MAKING A VACCINE
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United States of America Patent
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Issued Date -
Aug 11, 2011
app pub date -
Oct 11, 2009
filing date -
Oct 11, 2008
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Abstract
The present invention provides a vaccine and method for making same which is effective to elicit a desired antibody against a target antigen comprising a primary immunogen and a secondary immunogen, wherein the primary immunogen is effective to elicit B cell receptors (BCRs) that are on the maturational pathway of the desired antibody and have an intermediate degree of somatic mutational diversity, and the secondary immunogen comprises an epitope of the desired target antibody and is effective to further diversify the BCRs sufficient to form mature BCRs having the identical or substantially identical sequence as the desired antibody.
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