METHOD FOR DETECTING HEPATIC INJURY DUE TO ANTITHYROID DRUG
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United States of America Patent
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Issued Date -
Aug 4, 2011
app pub date -
Jan 20, 2011
filing date -
Feb 3, 2010
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Abandoned
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Abstract
The present invention relates a detecting method of distinguishing a temporary liver function test abnormalities by a thyrotoxicosis from a drug-induced hepatic injury by an antithyroid drug using a blood test and the likes, which is performed in a simple manner and with specificity. In the course of treating Graves' disease using an antithyroid drug, it is possible to differentiate a temporary liver function test abnormalities resulted from a thyrotoxicosis from a drug-induced hepatic injury resulted from the antithyroid drug, and therefore to detect the drug-induced hepatic injury with specificity by assaying a level of OCT in a body sample from a patient. In other words, it is possible to diagnose as a drug-induced hepatic injury if a blood OCT level in the sample from the patient is elevated compared to a level prior to administering the antithyroid drug or a blood OCT level from normal persons. Meanwhile, if the OCT level is not changed in spite of elevated levels of transaminases in the sample, it is possible to continue the treatment without discontinuing the drug administration since liver function test abnormalities in this case can be judged as temporary abnormalities owing to metabolic alteration, not as a drug-induced hepatic injury.
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