Peptide Stabilizer Compounds and Screening Method
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United States of America Patent
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Issued Date -
Aug 4, 2011
app pub date -
Mar 16, 2006
filing date -
Mar 16, 2005
priority date (Note) -
Abandoned
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Abstract
Peptide stabilizer compounds are provided that in combination with a biologically active peptide, can increase the protease elimination half-time of the biologically active peptide in vivo. The peptide stabilizer compounds are preferably in the form of peptide sequences that confer resistance to proteolysis upon conjugated biologically active peptides. Also provided is a method for the selection of novel proteolysis resistant compounds from in vitro generated libraries, and pharmaceutical compositions comprising the stabilizer compounds identified thereby.
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