Method for Producing Peptide Thioester
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United States of America Patent
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Issued Date -
Jul 28, 2011
app pub date -
Oct 5, 2007
filing date -
Oct 6, 2006
priority date (Note) -
Abandoned
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Abstract
An object of the present invention is to provide a method for synthesizing a peptide thioester by using a compound that can be easily obtained within a relatively short time under conditions in which a side reaction is unlikely to occur. In the present invention, a thioester bond is formed by elongating a peptide chain using N-alkyl cysteine as the C-terminal amino acid according to the Fmoc method, carrying out deprotection, and then causing the peptide bond to undergo N—S transfer to the thiol group of N-alkyl cysteine under weak acidic conditions.
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