Methods and Compositions for Inhibiting Fungal Infection and Disease
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United States of America Patent
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Issued Date -
Jul 28, 2011
app pub date -
Dec 14, 2010
filing date -
Dec 16, 2009
priority date (Note) -
Abandoned
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Abstract
, and integrins on host cells. The SAPs secure entry into the host cell through RGD-like binding motifs and subsequently induce apoptosis, thereby clearing the way for systemic infection. The invention thus provide a new target for therapeutic intervention and describes peptides and antibodies that inhibit the action of SAPs in this context, including their interaction with integrins.
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