METHOD FOR SELECTIVE DEPLETION OF CD137 POSITIVE CELLS USING ANTI-CD137 ANTIBODY-TOXIN COMPLEX
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United States of America Patent
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Issued Date -
Jul 21, 2011
app pub date -
Sep 30, 2010
filing date -
Jan 19, 2010
priority date (Note) -
Abandoned
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Abstract
The present invention relates to method for depletion of CD137 positive cells using an anti-CD137 antibody-toxin complex, and more particularly, to a method for selective depletion of CD137 positive cells, comprising the step of contacting an anti-CD137 antibody-toxin complex with the CD137 positive cells. The method for selective depletion of CD137 positive cells in accordance with the present invention can be useful to prevent or treat various diseases including immune diseases mediated by the activation of the CD137 positive cells because this method is excellent in delivering a complex of an anti-CD137 antibody, specific to CD137 molecules, and a toxin to CD137 expressing cells and selectively killing the CD137 positive cells alone and is also excellent in suppressing cell proliferation.
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