System for the Determination of Molecules Altering the Function of Interferon, Method Therefor and Compounds Altering Interferon Activity
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United States of America Patent
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Issued Date -
Jul 14, 2011
app pub date -
Jun 26, 2009
filing date -
Jun 27, 2008
priority date (Note) -
Abandoned
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Abstract
In a first aspect, cyclic peptides are provided identified as molecules altering the interferon activity, namely, inhibiting interferon response. Moreover, the present invention relates to a transgenic animal or parts thereof and a method for the determination of molecules and compounds altering the function of interferons, in particular, type I and type II interferon. In particular, said transgenic animal or parts thereof contain large parts of exogenous chromosomal DNA, namely interferon responsive DNA promoter elements operably linked with a nucleic acid sequence encoding a reporter or marker molecule. These a transgenic animal or parts thereof are useful in the methods according to the present invention.
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