Knitted biodegradable silk fabric comprising yarn promoting ingrowth of cells and methods of making
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United States of America Patent
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Jan 21, 2014
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app pub date -
Mar 24, 2011
filing date -
Nov 16, 2001
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Abstract
Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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