SUPPRESSION OF NEUROENDOCRINE DISEASES
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United States of America Patent
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Issued Date -
Jul 14, 2011
app pub date -
Jun 11, 2009
filing date -
Jun 12, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumour cell, preferably via a somatostatin or cortistatin receptor, a GHRH receptor, a ghrelin receptor, a bombesin receptor, a urotensin receptora melanin-concentrating hormone receptor 1; a KiSS-1 receptor or a prolactin-releasing peptide receptor. When so delivered, the protease is internalised and inhibits secretion—from said tumourcell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
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