Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof
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United States of America Patent
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app pub date -
Feb 4, 2010
filing date -
Jun 30, 1999
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Abstract
The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
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