METHODS FOR MODIFYING, ISOLATING, DETECTING, VISUALIZING, AND QUANTIFYING CITRULLINATED AND/OR HOMOCITRULLINATED PEPTIDES, POLYPEPTIDES AND PROTEINS
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United States of America Patent
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Issued Date -
Jul 7, 2011
app pub date -
Jun 12, 2008
filing date -
Jun 15, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention relates to methods and compositions for modifying, isolating, detecting, visualizing, and quantifying citrulline and/or homocitrulline-containing peptides, polypeptides, and proteins using mono- and disubstituted glyoxal derivatives. The invention also provides kits for modifying, isolating, detecting, visualizing, and quantifying the relative amounts of citrulline and/or homocitrulline-containing peptides, polypeptides, or proteins in solutions or samples.
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