INFLUENZA CAP-LEADER SEQUENCE

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United States of America Patent

APP PUB NO 20110165226A1
SERIAL NO

12993829

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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(A/U/G)−A/U−AGC. Further comprised are modified cap-leader sequences that are able to block elongation by the viral polymerase or cleavage by the viral endonuclase. Such modified cap-leader sequences comprise a 3′-terminal phosphate group, one or more phosphorothioate or phosphorodiamidate bonds or one ore more morpholino rings. Also pharmaceutical products comprising such a modified cap-leader sequence are disclosed. Further, the invention comprises methods for inhibiting virus transcription, especially for influenza virus, using such a modified cap-leader sequence or pharmaceutical product.

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Patent Owner(s)

Patent OwnerAddress
WAGENINGEN UNIVERSITEITDROEVENDAALSESTEEG 4 WAGENINGEN 6708 PB

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kormelink, Richard Jozef Maria Amersfoort, NL 1 0

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