FENOFIBRATE FORMULATION WITH ENHANCED ORAL BIOAVAILABILITY
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United States of America Patent
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Issued Date -
Jun 30, 2011
app pub date -
Jun 26, 2009
filing date -
Jul 3, 2008
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Abandoned
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Abstract
The present invention provides a formulation of fenofibrate with enhanced oral bioavailability, simplicity of design and manufacture and absence of food effect. The formulation comprises fenofibrate dissolved in a lipophilic surfactant, with a hydrophilic surfactant optionally added. The formulation can be effectively used in the management and treatment of conditions such as hypertriglyceridemia, hypercholesterolemia and mixed dyslipidemia, and can also be effective at lower doses as compared to commercially available products. The invention additionally relates to the process of manufacture of the formulation and to dosage forms comprising the same.
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