METHOD FOR DETECTING THE DRUG EFFECTS OF DNA METHYLATION-INHIBITORS
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United States of America Patent
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Issued Date -
Jun 30, 2011
app pub date -
Aug 28, 2009
filing date -
Aug 29, 2008
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Abandoned
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Abstract
Disclosed is a method for detecting the drug effects of DNA methylation inhibitors that detects the drug sensitivity of gene-expressing cells to DNA methylation inhibitors based on gene expression of a transcription factor (PU. 1) and/or gene expression of metallothionein (MT) that participates in differentiation to neutrophil and monocyte lines or based on DNA methylation in the metallothionein (MT) gene promotor region. Hematopoietic tumors can be treated effectively and specifically after predicting the effects of DNA methylation inhibitors on the hematopoietic tumor cells of myelodysplastic syndrome, acute myelocytic leukemia (AML), and other hematopoietic organ diseases, so therapeutic results are improved.
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