2,3-Substituted Fused Pyrimidin -4 (3H)-Ones as VR1 Antagonists
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United States of America Patent
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Issued Date -
Jun 23, 2011
app pub date -
Mar 21, 2006
filing date -
Mar 24, 2005
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Abandoned
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Abstract
alkyl, a five-membered heteroaromatic ring containing 1, 2 or 3 heteroatoms independently chosen from O, N and S, providing that no more than one O or S atom is present, or a six-membered heteroaromatic ring containing 1, 2 or 3 N atoms; or a pharmaceutically acceptable salt or N-oxide thereof; pharmaceutical compositions comprising them; the compounds for use in methods of treatment; and use of the compounds for manufacturing medicaments for treating pain as VR1 antagonists, including conditions such as depression, GERD, itch and urinary incontinence.
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