METHOD OF DETECTION AND/OR TITRATION IN VITRO OF AN UNCONVENTIONAL TRANSMISSIBLE AGENT
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United States of America Patent
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Issued Date -
Jun 23, 2011
app pub date -
Mar 25, 2009
filing date -
Mar 27, 2008
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Abandoned
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Abstract
The invention relates to an in vitro method for the in vitro detection and/or titration of a non-conventional transmissible agent (NCTA) or of a protein of pathological conformation, which is a marker for infectiousness related to the NCTA, in a sample, comprising: replication or propagation, in cells in culture, of the NCTA present in the sample, and then repeated incubation with a substrate which allows amplification of the NCTA or of the protein of pathological conformation, nonpathological conformer of the NCTA, before determination of the presence and/or of the amount of the NCTA or of the protein of pathological conformation in the sample.
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