Pharmaceutical Compositions of Amorphous Atorvasta and Process for Preparing Same
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United States of America Patent
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app pub date -
Feb 24, 2011
filing date -
Dec 2, 2004
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Abstract
Solid pharmaceutical compositions containing atorvastatin are disclosed. The compositions include a solid dispersion of amorphous atorvastatin and one or more optional pharmaceutically acceptable excipients. The solid dispersion is prepared by mixing crystalline atorvastatin with a melt-processible polymer and an optional stabilizer and an optional plasticizer at a temperature sufficiently high to soften or melt the polymer and to melt or dissolve the crystalline atorvastatin in the polymer, thereby forming a dispersion of amorphous atorvastatin.
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