Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof
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United States of America Patent
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Issued Date -
Jun 16, 2011
app pub date -
Jun 14, 2005
filing date -
Jun 14, 2004
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Abstract
The present invention relates to co-crystals of cetuximab Fab in a complex with extracellular domain of EGFR, and structure coordinates obtained from such crystal. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may for example inhibit binding of ligand to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.
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