POLYMER DERIVATIVE OF DOCETAXEL, METHOD OF PREPARING THE SAME AND USES THEREOF
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United States of America Patent
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Issued Date -
Jun 9, 2011
app pub date -
May 20, 2009
filing date -
May 23, 2008
priority date (Note) -
Abandoned
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Abstract
A method is provided for preparing a polymer derivative of docetaxel provided by an ester linkage between at least one hydroxyl group of docetaxel and a carboxyl group of an aspartic acid side chain of a block copolymer containing polyethylene glycol and polyaspartic acid, which method includes a step of adjusting the ratio and/or the number of docetaxel molecules linked to the block copolymer to thereby control the release rate of docetaxel from the resultant polymer derivative of docetaxel.
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