ANTICANCER COMPOUNDS AND SCREENING METHOD
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United States of America Patent
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Issued Date -
Jun 2, 2011
app pub date -
Nov 30, 2010
filing date -
Nov 30, 2009
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Abandoned
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Abstract
The invention provides a method to identify or characterize compounds for treating cancer wherein the compounds have a capacity to decrease systemic levels of one or more cholesterol metabolites in treated mammal(s). Such compounds include 17-(3-pyridyl)androst-5,16-diene-3β,7β-diol, 17-(2-morpholinyl)-7β-ethylandrost-5,16-diene-3β-ol, 17-(2-morpholinyl)-7β-ethylandrost-5,16-diene-3β-ol-16-acetate, 17-(4-oxazolyl)-7β-ethylandrost-5,16-diene-3β-ol-16-methyl ether and 17-(4-oxazolyl)-7β-ethylandrost-5,16-diene-3β-ol. Compositions and formulations comprising the compounds and one or more excipients are also provided.
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