METHODS AND MATERIALS FOR TARGETED AFFINITY ENHANCEMENT
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United States of America Patent
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Issued Date -
May 19, 2011
app pub date -
Dec 31, 2008
filing date -
Dec 31, 2007
priority date (Note) -
Abandoned
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Abstract
The present disclosure relates to materials and methods for enhancing the binding affinity of antibodies by introducing a number of targeted amino acid changes in antibody variable domains. The present disclosure provides novel methods of flowcharted amino acid change cycles, of identifying residues as members of unique proximity groups and of determining the degree of conspicuousness of amino acid residues in antibody variable regions. The disclosed methods are useful for the selection of variable region amino acid residues that are candidates for change to produce antibody variable domains with enhanced affinity for their binding partners.
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