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Abstract

This invention concerns a manufacturing process for nanoparticles composted of biodegradable polymers and active ingredients with therapeutic, cosmetic, veterinary, and alimentary applications, and a composition which contains said nanoparticles, which are used in products for animals, including humans. The process consists of emulsifying the hydrosoluble substances to form a w/o emulsion; dissolving the non-emulsionable substances, liposoluble polymer or polymer/compounds in organic solvents; mixing the w/o emulsion and the organic solution of the hydrophobics to form a pre-emulsioned mixture; adding the pre-emulsioned mixture, with the assistance of an injector system, to an aqueous emulsifier solution under ultradispersion to form the final emulsion; leading the final emulsion to evaporation, then centrifuge, freeze, and lyophilize. One variation of the method takes place when the hydrosoluble emulsioned compounds and the liposoluble polymer or polymer/compounds solution are injected separately over the aqueous emulsifying solution. The process of the invention allows nanoparticles of active ingredients to be obtained with a rigorous control over the size of the particle, preserving the active characteristics of the encapsulated compounds.

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First Claim