PROCESS FOR PREPARING O-DESMETHYLVENLAFAXINE
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Issued Date -
May 19, 2011
app pub date -
Oct 18, 2008
filing date -
Oct 26, 2007
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Abstract
The present invention provides a convenient and efficient process for the preparation of O-desmethylvenlafaxine (ODV), comprising the reaction of venlafaxine, or a salt thereof, with a thiol reagent such as a dithiol, an aminothiol or an inorganic thiol. The present invention also provides a process for purifying ODV base, said process comprising the steps of mixing crude ODV base with an alcohol to form a suspension and adding acid followed by base to generate ODV base with high purity.
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